• Skip to primary navigation
  • Skip to main content
  • Skip to footer

Human Research Protection Program

University of Southern CaliforniaResearch and Innovation
  • HRPP
  • Getting Started
  • Research
  • IRB
  • Expanded Access
You are here: Home / Research / IRB Authorization Agreements

IRB Authorization Agreements

USC promotes and engages in agreements by which an IRB relies on the review conducted by another entity. These agreements vary in scope, terms, and terminology. These agreements are designed to reduce duplication and increases efficiency by designating a single IRB review when more than one site is involved in a research project. Among the commonly used reliance agreements are:

  • IRB Authorization Agreement (IAA)
  • Memoranda of Understanding (MOU)
  • IRB Authorization Agreements (IRBAA)
  • Master Reliance Agreement (MRA)
  • Collaborative Review Agreement (CRA)

SMART IRB will be used as the primary reliance agreement when USC IRB is serving as the IRB if record. If the relying institution is not associated with SMART IRB, the USC IRB Authorization Agreement form will be completed.

Agreements to which USC is a party

  • Advarra External IRB Authorization & Reliance Agreement (LA General)
  • Advarra External IRB Authorization & Reliance Agreement (HSC)
  • Advarra External IRB Authorization & Reliance Agreement (UPC)
  • Hoag-USC Master Collaborative Research Study Agreement
  • National Cancer Institute’s Central IRB (IRBAA)
  • NIH StrokeNet/University of Cincinnati CIRB Authorization Agreement
  • RAND American Life Panel (IRBAA)
  • Schulman IRBAA Global Alzheimer’s Platform (GAP)
  • Schulman IRBAA Cystic Fibrosis Therapeutics Development Network (TDN)
  • USC and DHS Ceded IRB Review (MOU)
  • USC-CHLA Ceded Review (MOU)
  • USC-Hebrew Union College (MOU)
  • USC and Rancho Los Amigos (CRA)
  • WCG (WIRB-Copernicus Group) Master Agreement

SMART IRB Master Common Reciprocal Institutional Review Board Authorization Agreement

SMART IRB Master Reliance Agreement

  • Vanderbilt SMART IRB Letter of Indemnification for LA General
  • Vanderbilt SMART IRB Letter of Indemnification for USC
  • John Hopkins SMART IRB Letter of Indemnification for LA General
  • John Hopkins SMART IRB Letter of Indemnification for USC

Footer

HRPP

3720 S. Flower Street, Suite 325
Los Angeles, CA 90089

HRPP@usc.edu
(323) 442-0114

Full Accreditation badge from the Association for the Accreditation of Human Research Protection Programs

About Us

  • Home
  • Announcements
  • Getting Started
  • Internal Staff Webpage
  • HRPP
    • Contact
    • Education & Certification
    • HRPP Performance & Metrics
    • Policies and Procedures
    • Post Approval Monitoring (PAM)
    • Youtube Channel

Research

  • Biomedical Research
    • Research Repositories
    • Investigational Drugs and Devices
    • Investigator-Initiated Trials
    • Emergency Research
  • SBIRB Social Behavioral Research
  • Student Researchers
  • Reliance Agreements
    • Requesting USC to Rely on an External IRB
    • Requesting USC IRB to Act as the sIRB
  • Starting a Research Trial: the Basics

IRB

  • IRB FAQs
  • Forms and Templates
  • FWA and IRB Registration Numbers
  • IRB Member Toolbox
  • IRB Review: How to
  • IRB Submission Guidelines
  • Levels of IRB Review
  • Not Human Subjects Research (NHSR)
  • Post IRB Review and Approval
  • Privacy, Confidentiality, and Anonymity in Human Subjects Research
  • Urgent Review

HRPP
3720 S. Flower Street, Suite 325
Los Angeles, CA 90089
oprs@usc.edu
irb@usc.edu
(323) 442-0114

Full Accreditation badge from the Association for the Accreditation of Human Research Protection Programs
University of Southern California   Content managed by HRPP
  • Privacy Notice - Notice of Non-Discrimination